Investigation of Alterations in Hormone Levels in Saudi Patients Affected by COVID-19

Saleh N. Alghamdi, Firoz Ahmed, Ammar Alfargh, Mohamed Afifi

Abstract


Background: COVID-19 pandemic has posed significant challenges to global healthcare systems, with emerging evidence suggesting a potential impact on endocrine function. This study aimed to investigate the impact of COVID-19 infection on some important body hormones.

Methods: Eighty three (83) individuals hospitalized with COVID-19 infection and 15 healthy one participated in this study to investigate the alterations in thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (PTH), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH).

Results: The results indicated that, COVID 19 infection accompanied with a decrease in the levels of TSH, T3, ACTH in both diseased male and females, while the levels of estrogen and progesterone deceased in diseased females and testosterone levels decreased in diseased males as compared with non-diseased concomitant group. Inversely, the levels of PTH, PRL, LH and cortisol, increased in diseased male and female groups as compared with the concomitant non-diseased groups.

Conclusion: These findings suggest that COVID-19 has a substantial impact on hormonal balance, potentially necessitating clinical monitoring and management. Future research should explore the long-term endocrine effects of COVID-19.

Keywords

COVID-19, SARS-CoV-2, Hormones, Patient cohort


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References


Ren LL, Wang YM, Wu ZQ, Xiang ZC, Guo L, et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chinese Medical Journal (English), (2020); 133(9): 1015-1024.

Lee EC, Wada NI, Grabowski MK, Gurley ES, Lessler J. The engines of SARS-CoV-2 spread. Science, (2020); 370(6515): 406-407.

Hoffmann M, Kleine-Weber H, Schroeder S, Krger N, Herrler T, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, (2020); 181(2): 271-280.e8.

Ahmed F, Sharma M, Al-Ghamdi A, Al-Yami SM, Al-Shehri A, et al. A comprehensive analysis of cis-acting RNA elements in the SARS-CoV-2 genome by a bioinformatics approach. Frontiers in Genetics, (2020); 11: 1385.

Uddin M, Mustafa F, Rizvi TA, Loney T, Suwaidi HA, et al. SARS-CoV-2/COVID-19: viral genomics, epidemiology, vaccines, and therapeutic interventions. Viruses, (2020); 12(5).

Singh SJ, Barradell AC, Greening NJ, Bolton CE, Jenkins G, et al. Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation. Lancet Respiratory Medicine, (2023); 11(8): 709-725.

Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality. International Journal of Antimicrobial Agents, (2020); 55(5): 105954.

Wang T, Du Z, Zhu F, Cao Z, An Y, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. The Lancet, (2020); 395(10228): e52.

Akin L, Gzel MG. Understanding dynamics of pandemics. Turkish Journal of Medical Sciences, (2020); 50(SI-1): 515-519.

abuk SA, Cevher AZ, Kkardal? Y. Thyroid function during and after COVID-19 infection: a review. touchREVIEWS in Endocrinology, (2022); 18(1): 58-62.

De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, et al. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid, (2011); 21(8): 879-890.

Ruggeri RM, Campenn A, Siracusa M, Frazzetto G, Gullo D. Subacute thyroiditis in a patient infected with SARS-CoV-2: an endocrine complication linked to the COVID-19 pandemic. Hormones (Athens), (2021); 20(1): 219-221.

Szczerbi?ski ?, Okruszko MA, Szab?owski M. Long-term effects of COVID-19 on the endocrine system: a pilot case-control study. Frontiers in Endocrinology (Lausanne), (2023); 14: 1192174.

Chen M, Zhou W, Xu W. Thyroid function analysis in 50 patients with COVID-19: a retrospective study. Thyroid, (2021); 31(1): 8-11.

Lania A, Sandri MT, Cellini M, Mirani M, Lavezzi E, et al. Thyrotoxicosis in patients with COVID-19: the THYRCOV study. European Journal of Endocrinology, (2020); 183(4): 381-387.

Hadlow NC, Rothacker KM, Wardrop R, Brown SJ, Lim EM, et al. The relationship between TSH and free T4 in a large population is complex and nonlinear and differs by age and sex. Journal of Clinical Endocrinology and Metabolism, (2013); 98(7): 2936-2943.

Walsh JP. Thyroid function across the lifespan: do age-related changes matter? Endocrinology and Metabolism (Seoul), (2022); 37(2): 208-219.

Al-Kuraishy HM, Al-Gareeb AI, Qusti S, Al-Maiahy TJ, Cruz-Martins N, et al. The crucial role of prolactin-lactogenic hormone in COVID-19. Molecular and Cellular Biochemistry, (2022); 477(5): 1381-1392.

Cai Z, Zhong J, Jiang Y, Zhang J. Associations between COVID-19 infection and sex steroid hormones. Frontiers in Endocrinology, (2022); 13: 940675.

Wang S, Zhang A, Pan Y, Li X, Jiang W, et al. Association between COVID-19 and male fertility: systematic review and meta-analysis of observational studies. World Journal of Mens Health, (2023); 41(2): 311-329.

Gullo G, Lopez A, Loreto C, Rizzo F, Gullo A, et al. COVID-19 and female fertility: an observational prospective multicenter cohort study: upholding reproductive rights in emergency circumstances. Diagnostics (Basel), (2024); 14(19): 2118.

Voros C, Mavrogianni D, Minaoglou A, Kaltsas G, Vassiliadi DA, et al. Unveiling the impact of COVID-19 on ovarian function and premature ovarian insufficiency: a systematic review. Biomedicines, (2025); 13: 407.

Salonia A, Pontillo M, Capogrosso P, Rastrelli G, DellOglio P, et al. Severely low testosterone in males with COVID-19: a case-control study. Andrology, (2021); 9(4): 1043-1052.

Salciccia S, Moriconi M, Asero V, De Berardinis E, Busetto GM, et al. Systematic review and meta-analysis of serum total testosterone and luteinizing hormone variations across hospitalized COVID-19 patients. Scientific Reports, (2024); 14: 2786.

Mohammed GF, Saad HM. Severe COVID-19 has low testosterone, oestrogen levels, and impaired sexuality. Sexologies, (2022); 31(4): 477-486.

MacArthur T, Goswami J, Ramachandran D, Klein DA, Toth TL, et al. Estradiol and dihydrotestosterone levels in COVID-19 patients. Mayo Clinic Proceedings, (2023); 98(4): 559-568.

Amiri-Dashatan N, Koushki M, Parsamanesh N, Chiti H. Serum cortisol concentration and COVID-19 severity: a systematic review and meta-analysis. Journal of Investigative Medicine, (2022); 70(3): 766-772.

Porntharukchareon T, Dechates B, Sirisreetreerux S, Chantarangsu S, Phowthongkum P, et al. The existence of adrenal insufficiency in patients with COVID-19 pneumonia. Frontiers in Endocrinology, (2024); 15: 1337652.




DOI: https://doi.org/10.62940/als.v13i3.3838

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