Relationship between Interleukin 6 (Il-6) and Leptin Levels with BMI (Body Mass Index) in Schizophrenia Patients Receiving Antipsychotic Therapy

Audina Maharani, Dita Hasni, Ade Yuli Amellia, Eko Perdana Putra, Gangga Mahatma

Abstract


Background: Schizophrenia is a severe mental disorder . Although antipsychotic medication is essential for symptom control, it may contribute to weight gain and other metabolic abnormalities. Changes in pro-inflammatory cytokines have also been reported in patients with schizophrenia IL-6 and leptin are involved in inflammatory and metabolic processes in schizophrenia and may be associated with changes in Body Mass Index (BMI).

Methods: This cross-sectional study analyzed stored serum samples from 34 patients with schizophrenia who were receiving antipsychotic treatment at Prof. HB Saanin Mental Hospital, Padang. Stored serum samples were selected using convenience sampling. Eligible samples were obtained from patients aged 1865 years who had a confirmed diagnosis of schizophrenia and complete demographic data.

Results: Serum IL-6 was not correlated with BMI (r = ?0.008, p = 0.962). Leptin showed a weak positive correlation with BMI, but the association was not statistically significant (r = 0.224, p = 0.202).

Conclusion: Serum IL-6 and leptin levels were not significantly associated with BMI in schizophrenia patients receiving antipsychotic therapy. Future research using larger, multi-center cohorts is necessary to clarify how systemic inflammation and body composition interact in this patient group.

Keywords

Antipsychotics, BMI, Leptin, Schizophrenia, Weight gain


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DOI: https://doi.org/10.62940/als.v13i3.3481

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